Cricket Ireland said “full support” would be given to Maguire, who was not selected for Sunday’s match despite being permitted to continue bowling in international cricket until the test results are known.
Ireland struggled to contain the India batters with captain Smriti Mandhana (73) and Pratika Rawal (67) putting on 156 for the opening partnership and the hosts won the toss.
Rodrigues and Deol then combined for a 183-run stand as India posted a daunting target.
The tourists lost skipper Gaby Lewis for 12 before her opening partner Sarah Forbes (38) and Coulter Reilly took Ireland to 87-1.
After Forbes fell, Coulter Reilly and Laura Delany (37) put on 83 for the fourth wicket, but Ireland were well behind the required run-rate.
They could only manage 254-7 from their 50 overs with Deepti Sharma taking 3-37, while Orla Prendergast was the pick of the Irish bowlers with 2-75.
“The toss did have a part to play in it – it is a nice batting wicket but I don’t think we bowled well enough in the first 10-15 overs,” said Irish captain Lewis.
“When we came into the series all we asked for was progress. That’s what we did from game one to game two. We scored more runs in this game and hopefully we can do in the final match and sneak a win.”
The sides will meet at the Niranjan Shah Stadium again on Wednesday for the third and final ODI.