The British and Irish Lions game against the Sharks went ahead on Wednesday despite one player and one of the management team testing positive for coronavirus.
Eight players and four staff are isolating as close contacts, with eight changes made to the matchday squad.
Organisers said all other members of the touring party had tested negative.
A statement released an hour before kick-off said a medical advisory group had confirmed the game could be played.
“We see it as a positive,” British and Irish Lions managing director Ben Calveley told Sky Sports.
“We are showing that we can overcome all the challenges that face us and we are determined that we can put a tour on.”
Saturday’s game against the Bulls was postponed because of Covid-19 cases in the hosts’ camp, while South Africa’s match against Georgia was cancelled.
The Lions are due to face the Springboks in a three-Test series beginning on 24 July.
“The Test series is paramount,” Calveley continued.
“Our intention is to do everything we can to get those matches over the line here in South Africa. At the moment there is no intention to deviate from the schedule.”
After months of uncertainty, organisers opted to go ahead with the South Africa tour rather than pursue contingency plans to play at home or in Australia.
The Lions – who have been playing and training in a strict coronavirus bubble – arrived as South Africa was battling a third wave of infections, with the Springboks having to isolate twice in the past two weeks.
