Geraint Thomas will be among three Tour de France winners competing in the Etoile de Besseges, a five-day race that begins on Wednesday, 3 February.
The 34-year-old Welshman will be joined by Team Ineos colleague Egan Bernal and Vincenzo Nibali of Trek-Segafredo.
Team Ineos’ line-up also includes Thomas’ Welsh compatriot Owain Doull.
Thomas pulled out of his last race, the 2020 Giro d’Italia, after being injured in a fall, bringing a disappointing end to a disrupted year.
The coronavirus pandemic saw many races cancelled while the main event – the Tour – was delayed until August.
But it went ahead without Thomas, who instead concentrated on the Giro, only for misfortune to strike as he fell and fractured a hip after colliding with a discarded bottle.
He then welcomed the chance to mentally “switch off”, but is now looking forward to returning to action.