Serie A leaders Napoli suffered only their second league defeat of the season as they lost at home to Lazio, who moved up to second in the table.
Matias Vecino scored the only goal in the 67th minute with an excellent strike from outside the penalty area.
Serie A top goalscorer Victor Osimhen, with 19 goals in the league, came closest to an equaliser but saw his header bounce off the crossbar.
Lazio’s Sergej Milinkovic-Savic also hit the woodwork with a free-kick.
Vecino’s goal was the first goal Napoli had conceded in six games.
Napoli are aiming to become Italian champions for the third time with their last success coming in 1990.
Despite this loss, they are still in a dominant position as they are 17 points clear of Lazio, who move one point above Inter and AC Milan with the Milan clubs both having a game in hand.
AC Milan play at Fiorentina on Saturday before Inter entertain Lecce on Sunday.
Line-ups
Napoli
Formation 4-3-3
- 1Meret
- 22Di Lorenzo
- 13Rrahmani
- 3Kim Min-jae
- 17OliveraSubstituted forZedadkaat 90+3′minutes
- 99Zambo AnguissaSubstituted forElmasat 71′minutesBooked at 89mins
- 68LobotkaSubstituted forNdombéléat 82′minutes
- 20ZielinskiSubstituted forSimeoneat 82′minutes
- 11LozanoSubstituted forPolitanoat 71′minutes
- 9OsimhenBooked at 63mins
- 77Kvaratskhelia
Substitutes
- 4Demme
- 5Nunes Jesus
- 7Elmas
- 12Marfella
- 18Simeone
- 19Bereszynski
- 21Politano
- 23Zerbin
- 31Zedadka
- 55Østigård
- 70Gaetano
- 91Ndombélé
- 95Gollini
Lazio
Formation 4-3-3
- 94Provedel
- 77MarusicBooked at 90mins
- 4Gabarrón GilBooked at 21mins
- 13Romagnoli
- 23Hysaj
- 21S Milinkovic-Savic
- 5Vecino
- 10Romero AlconchelSubstituted forCataldiat 88′minutes
- 7Felipe AndersonSubstituted forPedroat 59′minutes
- 17Immobile
- 20ZaccagniSubstituted forCancellieriat 82′minutes
Substitutes
- 1Arantes Maximiano
- 3Pellegrini
- 6Marcos Antônio
- 9Pedro
- 11Cancellieri
- 18Romero
- 26Radu
- 29Lazzari
- 31Adamonis
- 32Cataldi
- 34Gila
- 88Basic
- 96Fares
Live Text
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Match ends, Napoli 0, Lazio 1.
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Second Half ends, Napoli 0, Lazio 1.
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Offside, Napoli. Amir Rrahmani tries a through ball, but Victor Osimhen is caught offside.
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Attempt blocked. Matteo Politano (Napoli) left footed shot from outside the box is blocked. Assisted by Khvicha Kvaratskhelia.
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Adam Marusic (Lazio) is shown the yellow card for a bad foul.
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Giovanni Simeone (Napoli) wins a free kick in the defensive half.
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Foul by Adam Marusic (Lazio).
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Substitution, Napoli. Karim Zedadka replaces MathÃas Olivera.
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Foul by Giovanni Simeone (Napoli).
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Matteo Cancellieri (Lazio) wins a free kick on the right wing.
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Sergej Milinkovic-Savic (Lazio) hits the right post with a right footed shot from outside the box from a direct free kick.
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Eljif Elmas (Napoli) is shown the yellow card for a bad foul.
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Foul by Eljif Elmas (Napoli).
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Matteo Cancellieri (Lazio) wins a free kick in the attacking half.
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Substitution, Lazio. Danilo Cataldi replaces Luis Alberto.
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Tanguy Ndombélé (Napoli) wins a free kick in the defensive half.
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Foul by Ciro Immobile (Lazio).
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Attempt blocked. Matteo Cancellieri (Lazio) left footed shot from outside the box is blocked. Assisted by Sergej Milinkovic-Savic.
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Tanguy Ndombélé (Napoli) wins a free kick in the defensive half.
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Foul by Sergej Milinkovic-Savic (Lazio).
