Nadal missed the US Open because he said he would not “be able to give my 100% at this time”.
He then pulled out of the Laver Cup earlier in September, saying he believed there are “other players who can help the team deliver the win”.
Nadal also missed the Australian Open in January through injury and decided not to play Wimbledon to focus on the Olympics.
He previously hinted at retirement later this year, but said before the French Open he was not “100%” certain that would be the last time he played at Roland Garros.
The Davis Cup quarter-finals take place 19-21 November, with the semi-finals following on consecutive days before the final on Sunday, 24 November.
Reigning world number one Jannik Sinner is set to lead defending champions Italy, who will seek to become the first team to retain the title since 2013.
