Croatia captain Domagoj Vida played the first half of the 3-3 draw with Turkey before finding out he had tested positive for Covid-19.
The centre-back, 31, was already scheduled to be replaced.
A statement said: “Vida will, in accordance with regulations, spend the next few days in self-isolation in Istanbul.”
The rest of the squad will now travel to Sweden for a Nations League match on Saturday.
All players and staff had tested negative on Monday, but further tests on Wednesday morning found Vida to be positive.
The Croatia medical team received initial information on “one potentially positive result” during half-time in the friendly.
The Besiktas defender, who had already been replaced by Filip Uremovic, isolated while the result in question was retested, before confirmation came that he was positive.
He will miss the Sweden game and the Nations League fixture against Portugal on Tuesday.
Apart from Vida one member of Croatia party, who was not in contact with players or staff members, also tested positive.
Line-ups
Turkey
- 23Çakir
- 14Sangaré
- 15ÇetinSubstituted forYaziciat 45′minutes
- 4KabakBooked at 38mins
- 18ErkinSubstituted forBayramat 45′minutes
- 5Yokuslu
- 8TokozSubstituted forDemiralat 54′minutes
- 7ÃœnderSubstituted forKaracaat 77′minutes
- 22KökcüSubstituted forÖzcanat 34′minutes
- 20Türüç
- 9TosunSubstituted forÃœnalat 63′minutes
Substitutes
- 1Günok
- 2Zeki Çelik
- 3Demiral
- 6Tufan
- 10Calhanoglu
- 11Yazici
- 12Bayindir
- 13Özcan
- 16Ãœnal
- 17Karaca
- 19Bayram
- 21Kahveci
Croatia
- 23Sluga
- 20Juranovic
- 21VidaSubstituted forUremovicat 45′minutes
- 6PongracicSubstituted forCaleta-Carat 61′minutes
- 22Melnjak
- 17Rog
- 19BadeljSubstituted forBasicat 60′minutes
- 7BrekaloSubstituted forPerisicat 60′minutesBooked at 85mins
- 15PasalicSubstituted forModricat 77′minutes
- 18Orsic
- 14BudimirSubstituted forColakat 66′minutes
Substitutes
- 1Grbic
- 2Uremovic
- 3Barisic
- 4Perisic
- 5Caleta-Car
- 8Kovacic
- 9Colak
- 10Modric
- 11Brozovic
- 12L Kalinic
- 13Vlasic
- 16Basic
Live Text
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Match ends, Turkey 3, Croatia 3.
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Second Half ends, Turkey 3, Croatia 3.
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Foul by Toma Basic (Croatia).
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Enes Ãœnal (Turkey) wins a free kick in the attacking half.
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Foul by Dario Melnjak (Croatia).
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Deniz Türüç (Turkey) wins a free kick on the right wing.
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Foul by Marko Rog (Croatia).
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Berkay Özcan (Turkey) wins a free kick in the attacking half.
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Ivan Perisic (Croatia) is shown the yellow card for a bad foul.
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Foul by Ivan Perisic (Croatia).
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Nazim Sangaré (Turkey) wins a free kick on the right wing.
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Hand ball by Ivan Perisic (Croatia).
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Luka Modric (Croatia) wins a free kick in the defensive half.
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Foul by Okay Yokuslu (Turkey).
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Foul by Ivan Perisic (Croatia).
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Deniz Türüç (Turkey) wins a free kick on the right wing.
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Substitution, Turkey. Efecan Karaca replaces Cengiz Ãœnder.
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Substitution, Croatia. Luka Modric replaces Mario Pasalic.
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Attempt missed. Enes Ãœnal (Turkey) right footed shot from outside the box is close, but misses to the left. Assisted by Yusuf Yazici.
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Foul by Duje Caleta-Car (Croatia).