Chelsea and Real Madrid secured their quarter-final places with victories on Wednesday – eliminating Celtic and Twente respectively.
Real Madrid came from a goal down to beat Twente 3-2 in Enschede, while Chelsea eased past Champions League debutants Celtic 3-0 at Stamford Bridge.
Lucy Bronze, Wieke Kaptein and Eve Perisset all got on the scoresheet as Sonia Bompastor extended her winning start to life at Chelsea to 12 games.
The Blues, 2020-21 runners-up in this competition, are currently top of the group with 12 points – three ahead of Madrid.
They will clinch top spot if they beat Twente next month and Madrid fail to beat Celtic, while a draw would be enough if the Spanish side lose.
However, if both sides win their penultimate fixtures then the final matchday will be crucial – Chelsea would need to avoid defeat in Spain on 17 December to progress as group winners.